Brain Tumour / Cancer

Targeting classical but not neurogenic inflammation reduces peritumoral oedema in secondary brain tumours. J. Neuroimmunol 250, 59-65.

Authors: Lewis KM, Harford-Wright E, Vink R, Ghabriel MN (2012)

Funding contributor: SA Police Ride Like Crazy


Towards Drug Discovery for Brain Tumours: Interaction of Kinins and Tumours at the Blood Brain Barrier Interface.

Authors: Elizabeth Harford-Wright, Kate M. Lewis, and Robert Vink (2011)

Keywords: CNS tumours · glioma · kinins · blood-brain barrier · substance P · bradykinin.

Funding contributor: SA Police Ride Like Crazy


Cytokine-mediated blood brain barrier disruption as a conduit for cancer/chemotherapy-associated neurotoxicity and cognitive dysfunction

Authors: Hannah R. Wardill, Kimberley A. Mander, Ysabella Z.A. Van Sebille, Rachel J. Gibson, Richard M. Logan, Joanne M. Bowen and Stephen T. Sonis (2016)

Keywords: neurotoxicity · cognitive dysfunction · blood brain barrier · inflammation · chemotherapy-induced gut toxicity


Advancing Drug Therapy for Brain Tumours: A Current Review of the Pro-inflammatory Peptide Substance P and its Antagonists as Anti-cancer Agents

Authors: Kimberley Mander, Elizabeth Harford-Wright, Kate M. Lewis, and Robert Vink (2014)

Keywords: Blood-brain barrier · CNS tumours · glioma · metastases · substance P · tight junctions

Funding contributor: SA Police Ride Like Crazy


Toll-like receptor 4 signaling: A common biological mechanism of regimen-related toxicities An emerging hypothesis for neuropathy and gastrointestinal toxicity

Authors: Hannah R. Wardill, Ysabella Z.A. Van Sebille, Kimberley A. Mander, Rachel J. Gibson, Richard M. Logan, Joanne M. Bowen, Stephen T. Sonis (2015)

Keywords: Chemotherapy · Neurotoxicity · Neuropathy · Gut toxicity · Toll-like receptor 4 · Glial activation


Walker 256 tumour cells increase substance P immunoreactivity locally and modify the properties of the blood-brain barrier during extravasation and brain invasion. Clin. Exp. Metastasis 30, 1-12.

Authors: Lewis KM, Harford-Wright E, Vink R, Nimmo AJ, Ghabriel MN (2013)

Funding contributor: SA Police Ride Like Crazy


NK1 Receptor antagonists and dexamethasone as anticancer agents in vitro and in a model of brain tumours secondary to breast cancer. Anti-Cancer Drugs 24, 344-54.

Authors: Lewis KM, Harford-Wright E, Vink R, Ghabriel MN (2013) NK1

Funding contributor: SA Police Ride Like Crazy


Characterization of Walker 256 breast carcinoma cells from two different tumour cell banks as assessed using two models of secondary brain tumours. Cancer Cell Int 13, 5.

Authors: Lewis KM, Harford-Wright E, Vink R, Ghabriel MN (2013)

Funding contributor: SA Police Ride Like Crazy


Characterization of Walker 256 breast carcinoma cells from two different tumour cell banks as assessed using two models of secondary brain tumours. Cancer Cell Int 13, 5.

Authors: Naomi Cook, Corinna Van Den Heuvel, and Robert Vink (2009)

Keywords: traumatic brain injury · brain magnesium · TRPM channels · ischaemic cell death


The potential for substance P antagonists as anti-cancer agents in brain tumours. Recent Pat. CNS Drug Disc. 8, 13-23.

Authors: Harford-Wright E, Lewis KM, Vink R (2013)

Funding contributor: SA Police Ride Like Crazy


Evaluating the role of substance P in the growth of brain tumors. Neuroscience 261, 85-94.

Authors: Harford-Wright E, Lewis KM, Vink R, Ghabriel MN (2014)

Funding contributor: SA Police Ride Like Crazy


Evaluating the role of substance P in the growth of brain tumors. Neuroscience 261, 85-94.

Authors: WW Blessing and E Nalivaiko (2000)

Keywords: caudal ventrolateral medulla · vasomotor neurons · arterial pressure


Treatment with the NK1 antagonist emend reduces blood brain barrier dysfunction and edema formation in an experimental model of brain tumors. PloS ONE 9 (5), e96891.

Authors: Harford-Wright E, Lewis KM, Ghabriel MN, Vink R (2014)

Funding contributor: SA Police Ride Like Crazy


The emerging role of sphingolipids in cancer stem cell biology. In Lipidomics of Stem Cells. pp. 151-170. Pebay A and Wong R (Eds). Springer International Publishing, Switzerland.

Authors: Lewis AC, Powell JA, Pitson SM (2017)

Funding contributor: SA Police Ride Like Crazy


The emerging role of sphingolipids in cancer stem cell biology. In Lipidomics of Stem Cells. pp. 151-170. Pebay A and Wong R (Eds). Springer International Publishing, Switzerland.

Authors: Renée Turner and Robert Vink (2007).

Keywords: neurogenic inflammation · ischaemic stroke · cerebral oedema · substance P


Neurodegeneration: Alzheimer’s, Parkinson’s, Concussion

A substance P mediated pathway contributes to 6-hydroxydopamine induced cell death.

Authors: Levon Gabrielian, Stephen C. Helps, Emma Thornton, Renée Turner, Anna Leonard, and Robert Vink (2013).

Keywords: Neurotrauma · Neurokinins · Tachykinins · Neurogenic inflammation · Rat · Sheep


Stroke & Oedema

A Surgical Model of Permanent and Transient Middle Cerebral Artery Stroke in the Sheep

Authors: Adam J. Wells, Robert Vink, Peter C. Blumbergs, Brian P. Brophy, Stephen C. Helps, Steven J. Knox, Renée J. Turner (2012)

Keywords: ischaemic stroke · large animal model · middle cerebral artery occlusion


Characterization of Walker 256 breast carcinoma cells from two different tumour cell banks as assessed using two models of secondary brain tumours. Cancer Cell Int 13, 5.

Authors: Timothy J. Kleinig and Robert Vink (2009)

Keywords: cytokines · edema · inflammasome · innate immunity · neuroprotection · therapy · thrombin


Treatment with the NK1 antagonist emend reduces blood brain barrier dysfunction and edema formation in an experimental model of brain tumors. PloS ONE 9 (5), e96891.

Authors: Renée Turner, Stephen C. Helps, Emma Thornton, Robert Vink (2011).

Keywords: Ischaemic stroke · NK1 tachykinin receptor antagonist · Oedema · Neuropeptides · Neurogenic inflammation


Treatment with the NK1 antagonist emend reduces blood brain barrier dysfunction and edema formation in an experimental model of brain tumors. PloS ONE 9 (5), e96891.

Authors: Renée Turner & Robert Vink (2012)

Keywords:

ischaemic stroke · NK1 tachykinin receptor antagonist · tissue plasminogen activator · blood brain barrier · neuropeptides · neurogenic inflammation


Reference genes for normalising gene expression data in collagenase-induced rat intracerebral haemorrhage.

Authors: Renée Turner and Frank Sharp (2016)

Keywords: metalloproteinases (MMP) · blood brain barrier · ischaemic stroke · haemorrhagic transformation · cerebral oedema · neutrophils · tPA


Substance P Antagonists as a Therapeutic Approach to Improving Outcome Following Traumatic Brain Injury.

Authors: Renée Turner and Robert Vink (2014)

Keywords: Neurogenic inflammation · Neuropeptides ·Ischemic stroke · Capsaicin · NK1 tachykinin receptor antagonist


Are the transient receptor potential melastatin (TRPM) channels important in magnesium homeostasis following traumatic brain injury?

Authors: Renée Turner and Robert Vink (2013).

Keywords: substance P · neuropeptides · neurogenic inflammation · cerebral oedema · stroke · tachykinin · blood-brain barrier · cerebral ischaemia


Traumatic Brain & Spinal Cord Injury

NK1 Receptor antagonists and dexamethasone as anticancer agents in vitro and in a model of brain tumours secondary to breast cancer. Anti-Cancer Drugs 24, 344-54.

Authors: Frances Corrigan, Chi Pham, Robert Vink, Peter Blumbergs, Colin Masters, Corinna Van Den Heuvel, and Roberto Cappai (2011)

Keywords: Amyloid precursor protein · Growth factor like domain · E2 domain · sAPPα · Traumatic brain injury


NK1 Receptor antagonists and dexamethasone as anticancer agents in vitro and in a model of brain tumours secondary to breast cancer. Anti-Cancer Drugs 24, 344-54.

Authors: James Donkin, Ibolja Cernak, Peter Blumbergs, and Robert Vink (2011)

Keywords: : neurogenic inflammation · neuropeptides · neurotrauma · neurokinin 1 (NK1) antagonist


NK1 Receptor antagonists and dexamethasone as anticancer agents in vitro and in a model of brain tumours secondary to breast cancer. Anti-Cancer Drugs 24, 344-54.

Authors: Emma Thornton, Tuyet Tran, and Robert Vink (2010)

Keywords: Parkinson’s disease · Substance P · Cell death, Organotypic co-culture · Dopaminergic neurone


NK1 Receptor antagonists and dexamethasone as anticancer agents in vitro and in a model of brain tumours secondary to breast cancer. Anti-Cancer Drugs 24, 344-54.

Authors: Naomi L Cook, Timothy Kleinig, Corinna Van Den Heuvel, and Robert Vink (2010)

Keywords: Intracerebral haemorrhage · RT-PCR · gene expression · normalisation · collagenase-induced ICH


NK1 Receptor antagonists and dexamethasone as anticancer agents in vitro and in a model of brain tumours secondary to breast cancer. Anti-Cancer Drugs 24, 344-54.

Authors: Robert Vink and Corinna Van Den Heuvel (2010)

Keywords: traumatic brain injury · Substance P · neurogenic inflammation · edema · NK1 receptor antagonist


NK1 Receptor antagonists and dexamethasone as anticancer agents in vitro and in a model of brain tumours secondary to breast cancer. Anti-Cancer Drugs 24, 344-54.

Authors: Robert Vink, Naomi Cook, and Corinna Van Den Heuvel (2009)

Keywords: traumatic brain injury · stroke · neurodegeneration · neonatal brain injury · brain magnesium


Characterization of Walker 256 breast carcinoma cells from two different tumour cell banks as assessed using two models of secondary brain tumours. Cancer Cell Int 13, 5.

Authors: Alan J. Nimmo and Robert Vink (2009)

Keywords: Brain injury · neuroinflammation · cytokines · chemokines · bradykinin · tachykinins.


Characterization of Walker 256 breast carcinoma cells from two different tumour cell banks as assessed using two models of secondary brain tumours. Cancer Cell Int 13, 5.

Authors: Naomi L. Cook, Robert Vink, James J. Donkin. and Corinna Van Den Heuvel (2009)

Keywords: real-time PCR · substance P · quantitation · rats · neurotraum


The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains.

Authors: James Cooper, Paul Myles, Francis McDermott, Lynette Murray, John Laidlaw, Gregory Cooper, Ann Tremayne, Stephen Bernard, and Jennie Ponsford (2004)

Keywords: hypotension · hypertonic saline · traumatic brain injury · neurological outcome


A Substance P Antagonist Reduces Axonal Injury and Improves Neurologic Outcome When Administered Up to 12 Hours after Traumatic Brain Injury.

Author: Roger J. Lewis (2004)

Keywords: prehospital care · hypertonic saline


The potential for substance P antagonists as anti-cancer agents in brain tumours. Recent Pat. CNS Drug Disc. 8, 13-23.

Authors: Prof Jeffrey Rosenfeld and A/Prof Cristina Morganti-Kossmann (2004)

Keywords: microdialysis · traumatic brain injury · hypoxia · neuroinflammation · cytokine expression


The potential for substance P antagonists as anti-cancer agents in brain tumours. Recent Pat. CNS Drug Disc. 8, 13-23.

Authors: Ibolja Cernak, Christine O’Connor and Robert Vink (2002)

Keywords: Neurotrauma · COX · Cognition · Diffuse axonal injury


The potential for substance P antagonists as anti-cancer agents in brain tumours. Recent Pat. CNS Drug Disc. 8, 13-23.

Authors: I Cernak, C O’Connor and R Vink (2000)

Keywords: diffuse axonal injury · neurological outcome · neurotrauma · nimesulide


The potential for substance P antagonists as anti-cancer agents in brain tumours. Recent Pat. CNS Drug Disc. 8, 13-23.

Authors: JN Garcia, NP Pedersen, E Nalivaiko, and WW Blessing (2001)

Keywords: skin blood flow · cutaneous blood flow · temperature regulation · stress · anxiety


Evaluating the role of substance P in the growth of brain tumors. Neuroscience 261, 85-94.

Authors: Ying-Hui Yu and WW Blessing (2000)

Keywords: carotid artery chemoreceptors · phenylbiguanide (PBG) · electroencephalogram (EEG)


Evaluating the role of substance P in the growth of brain tumors. Neuroscience 261, 85-94.

Authors: Diana Busingye, Renée Turner, Robert Vink (2016)

Keywords: Blood brain barrier · Edema · Magnesium · Neurotrauma · Treatment


Magnesium in acute and chronic brain injury: an update

Authors: Kelly McAteer, Frances Corrigan, Emma Thornton. Renée Turner, and Robert Vink (2016).

Keywords: repetitive mild traumatic brain injury (mTBI) · chronic trumatic encephalopathy (CTE) · tau phosphorylation · neuroinflammation


Hemoglobin crystals: A pro-inflammatory potential confounder of rat experimental intracerebral hemorrhage.

Authors: James Donkin, Renée Turner, Islam Hassan, Robert Vink (2007)

Keywords: neurotrauma · traumatic brain injury · edema · neuropeptides


Other: Aneurysms, Arteriovenous Malformation, Brain Haemorrhage, Moyamoya, Vascular Conditions

Nano-hemostats and a Pilot Study of Their Use in a Large Animal Model of Major Vessel Hemorrhage in Endoscopic Skull Base Surgery

Authors: Alistair Jukes, Jae Murphy, Sarah Vreugde, Alkis Psaltis, P. J. Wormald (2016)

Keywords: endoscopic transsphenoidal surgery · hemorrhage control · nano-medicine · pituitary surgery internal carotid artery injury


Magnesium in the Central Nervous System

Edited by Robert Vink and Mihai Nechifor (2012)

This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesium’s involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behaviour.


Automatic Nonsubjective Estimation of Antigen Content Visualized by Immunohistochemistry Using Color Deconvolution

Authors: Stephen Helps, Emma Thornton, Timothy Kleinig, Jim Manavis, and Robert Vink (2012)

Keywords: antigen estimation · color deconvolution · immunohistochemistry · virtual microscopy · brain


Characterization of Walker 256 breast carcinoma cells from two different tumour cell banks as assessed using two models of secondary brain tumours. Cancer Cell Int 13, 5.

Authors: Timothy Kleinig, Stephen Helps, Mounir Ghabriel, Jim Manavis, Christopher Leigh, Peter Blumbergs, and Robert Vink (2009)

Keywords: Hemoglobin · Inflammation · Intracerebral haemorrhage